A prospective, randomized double-blind study on the treatment of anal fissures with nitroglycerin ointment

Daphna Weinstein*, Ariel Halevy, Michael Negri, Ninet Levy, Ilana Gelertner, Yehiel Ziv

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Anal fissure is a common disease. Treatment includes conservative measures or surgery. One of the treatment options is topical Nitroglycerin ointment. Materials and Methods: We present a prospective, randomized, double-blind study, encompassing 48 patients suffering from chronic anal fissure. The subjects were divided into three groups according to the dose of Nitroglycerin ointment received - group I - 0% (placebo), group II - 0.2% (0.75 mg) and group III - 0.4% (1.5 mg). Demographic data, medical history and physical findings were recorded. Healing, pain relief and adverse events were evaluated during and after the treatment period. Results: No significant difference (p<0.05) was found between the groups with respect to patient age, gender, past history, physical examination, amount of ointment used and adverse events. Thirty three of the 48 (69%) patients completed the study. No significant differences were found between the groups with respect to the reasons and rates of leaving the study (p=0.494). Fifteen patients failed to complete the study eight patients (17%) due to headaches, one patient was operated upon and six patients left the study because of cooperation problems. No significant difference was found between the groups regarding healing (p=0.952) or pain relief (p=0.458-0.8) according to the type of pain checke. Conclusions: According to our study, there was no benefit regarding healing or pain relief, in treating patients suffering from an anal fissure with Nitroglycerin ointment in combination with stool softeners and sitz baths, compared to the same treatment without Nitroglycerin ointment.

Original languageEnglish
Pages (from-to)713-717
Number of pages5
JournalHarefuah
Volume143
Issue number10
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • Anal fissure
  • Chronic anal fissure
  • Fissure healing
  • Nitroglycerin ointment
  • Perianal pain

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