A prospective, longitudinal, observational cohort study examining how glaucoma affects quality of life and visually-related function over 4 years: Design and methodology Glaucoma

Michael Waisbourd, Samantha Parker, Feyzahan Ekici, Patricia Martinez, Rachel Murphy, Katie Scully, Sheryl S. Wizov, Lisa A. Hark, George L. Spaeth

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study is to summarize the design and methodology of a prospective, longitudinal, observational cohort study to investigate how glaucoma affects patients' quality of life and visually-related function over a 4-year period. Methods/Design: One hundred sixty-one (161) subjects were enrolled in this ongoing study. Patients between the ages of 21-85 years with a minimum 2-year diagnosis of primary open-angle glaucoma, chronic primary angle-closure glaucoma or pseudoexfoliation glaucoma were included. Each patient visited Wills Eye Hospital for a baseline visit. Follow-up is planned for a minimum of 4 years, with annual visits. Each visit includes (1) Clinical evaluation: a slit lamp examination, fundoscopy, intraocular pressure measurement, visual field examination, spectral domain optical coherence tomography, Pelli-Robson Contrast Sensitivity test and the Spaeth-Richman Contrast Sensitivity test; (2) a performance based measure: the Compressed Assessment of Ability Related to Vision; and (3) Subjective measures of vision-related quality of life (the National Eye Institute Visual Functioning Questionnaire 25 and the Modified Glaucoma Symptom Scale). Discussion: The results of this ongoing, prospective, longitudinal study are expected to shed light on the relationships between clinical measures, performance-based measures and subjective measures of well-being, in order to assess changes in the quality of life and the ability to function of patients with glaucoma over time.

Original languageEnglish
Article number91
JournalBMC Ophthalmology
Volume15
Issue number1
DOIs
StatePublished - 1 Aug 2015
Externally publishedYes

Keywords

  • Glaucoma
  • Performance-based measures
  • Vision-related quality of life

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