A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

B. Risslegger; T. Zoran; M. Lackner; M. Aigner; F. Sánchez-Reus; A. Rezusta; A. Chowdhary; S. J. Taj-Aldeen; M. C. Arendrup; S. Oliveri; D. P. Kontoyiannis; A. Alastruey-Izquierdo; K. Lagrou; G. Lo Cascio; J. F. Meis; W. Buzina; C. Farina; M. Drogari-Apiranthitou; A. Grancini; A. M. Tortorano; B. Willinger; A. Hamprecht; E. Johnson; L. Klingspor; V. Arsic-Arsenijevic; O. A. Cornely; J. Meletiadis; W. Prammer; V. Tullio; J. J. Vehreschild; L. Trovato; R. E. Lewis; E. Segal; P. M. Rath; P. Hamal; M. Rodriguez-Iglesias; E. Roilides; S. Arikan-Akdagli; A. Chakrabarti; A. L. Colombo; M. S. Fernández; M. T. Martin-Gomez; H. Badali; G. Petrikkos; N. Klimko; S. M. Heimann; J. Houbraken; O. Uzun; M. Edlinger; S. de la Fuente; C. Lass-Flörl

doi:10.1016/j.cmi.2017.04.012

A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

B. Risslegger, T. Zoran, M. Lackner, M. Aigner, F. Sánchez-Reus, A. Rezusta, A. Chowdhary, S. J. Taj-Aldeen, M. C. Arendrup, S. Oliveri, D. P. Kontoyiannis, A. Alastruey-Izquierdo, K. Lagrou, G. Lo Cascio, J. F. Meis, W. Buzina, C. Farina, M. Drogari-Apiranthitou, A. Grancini, A. M. TortoranoB. Willinger, A. Hamprecht, E. Johnson, L. Klingspor, V. Arsic-Arsenijevic, O. A. Cornely, J. Meletiadis, W. Prammer, V. Tullio, J. J. Vehreschild, L. Trovato, R. E. Lewis, E. Segal, P. M. Rath, P. Hamal, M. Rodriguez-Iglesias, E. Roilides, S. Arikan-Akdagli, A. Chakrabarti, A. L. Colombo, M. S. Fernández, M. T. Martin-Gomez, H. Badali, G. Petrikkos, N. Klimko, S. M. Heimann, J. Houbraken, O. Uzun, M. Edlinger, S. de la Fuente, C. Lass-Flörl^*

^*Corresponding author for this work

Clinical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

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Abstract

Objectives A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods A total of 370 cases from 21 countries were evaluated. Results The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.

Original language	English
Pages (from-to)	776.e1-776.e5
Journal	Clinical Microbiology and Infection
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.cmi.2017.04.012
State	Published - Oct 2017

Funding

Funders	Funder number
Aranis
Basilea and Merck
ECMM
EFISG	D-155110-017-016
F2G
German Federal Ministry of Research and Education
ISHAM
Inositec AG
Melinta Therapeutics
Merck/MSD
Pfizer & T2Candida
Sanofi Pasteur, Scynexis, Seres Therapeutics
Schering Plough
Sharpe & Dohme
United Medical
National Institutes of Health	UM1AI104681
Pfizer	WI182172
AstraZeneca
Bayer
Merck
Novartis
Roche
Gilead Sciences
Janssen Biotech
Actelion Pharmaceuticals
Duke University
Medpace
Meso Scale Diagnostics
Schering-Plough
Janssen Pharmaceuticals
Cidara Therapeutics
University of Leeds
GlaxoSmithKline Australia
Austrian Science Fund
Astellas Pharma
Basilea Pharmaceutica

Keywords

Amphotericin B
Aspergillosis
Aspergillus terreus
Crytic species
In vitrosusceptibility

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10.1016/j.cmi.2017.04.012

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Risslegger, B., Zoran, T., Lackner, M., Aigner, M., Sánchez-Reus, F., Rezusta, A., Chowdhary, A., Taj-Aldeen, S. J., Arendrup, M. C., Oliveri, S., Kontoyiannis, D. P., Alastruey-Izquierdo, A., Lagrou, K., Lo Cascio, G., Meis, J. F., Buzina, W., Farina, C., Drogari-Apiranthitou, M., Grancini, A., ... Lass-Flörl, C. (2017). A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study. Clinical Microbiology and Infection, 23(10), 776.e1-776.e5. https://doi.org/10.1016/j.cmi.2017.04.012

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title = "A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study",

abstract = "Objectives A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods A total of 370 cases from 21 countries were evaluated. Results The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.",

keywords = "Amphotericin B, Aspergillosis, Aspergillus terreus, Crytic species, In vitrosusceptibility",

author = "B. Risslegger and T. Zoran and M. Lackner and M. Aigner and F. S{\'a}nchez-Reus and A. Rezusta and A. Chowdhary and Taj-Aldeen, {S. J.} and Arendrup, {M. C.} and S. Oliveri and Kontoyiannis, {D. P.} and A. Alastruey-Izquierdo and K. Lagrou and {Lo Cascio}, G. and Meis, {J. F.} and W. Buzina and C. Farina and M. Drogari-Apiranthitou and A. Grancini and Tortorano, {A. M.} and B. Willinger and A. Hamprecht and E. Johnson and L. Klingspor and V. Arsic-Arsenijevic and Cornely, {O. A.} and J. Meletiadis and W. Prammer and V. Tullio and Vehreschild, {J. J.} and L. Trovato and Lewis, {R. E.} and E. Segal and Rath, {P. M.} and P. Hamal and M. Rodriguez-Iglesias and E. Roilides and S. Arikan-Akdagli and A. Chakrabarti and Colombo, {A. L.} and Fern{\'a}ndez, {M. S.} and Martin-Gomez, {M. T.} and H. Badali and G. Petrikkos and N. Klimko and Heimann, {S. M.} and J. Houbraken and O. Uzun and M. Edlinger and Fuente, {S. de la} and C. Lass-Fl{\"o}rl",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = oct,

doi = "10.1016/j.cmi.2017.04.012",

language = "אנגלית",

volume = "23",

pages = "776.e1--776.e5",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

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Risslegger, B, Zoran, T, Lackner, M, Aigner, M, Sánchez-Reus, F, Rezusta, A, Chowdhary, A, Taj-Aldeen, SJ, Arendrup, MC, Oliveri, S, Kontoyiannis, DP, Alastruey-Izquierdo, A, Lagrou, K, Lo Cascio, G, Meis, JF, Buzina, W, Farina, C, Drogari-Apiranthitou, M, Grancini, A, Tortorano, AM, Willinger, B, Hamprecht, A, Johnson, E, Klingspor, L, Arsic-Arsenijevic, V, Cornely, OA, Meletiadis, J, Prammer, W, Tullio, V, Vehreschild, JJ, Trovato, L, Lewis, RE, Segal, E, Rath, PM, Hamal, P, Rodriguez-Iglesias, M, Roilides, E, Arikan-Akdagli, S, Chakrabarti, A, Colombo, AL, Fernández, MS, Martin-Gomez, MT, Badali, H, Petrikkos, G, Klimko, N, Heimann, SM, Houbraken, J, Uzun, O, Edlinger, M, Fuente, SDL & Lass-Flörl, C 2017, 'A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study', Clinical Microbiology and Infection, vol. 23, no. 10, pp. 776.e1-776.e5. https://doi.org/10.1016/j.cmi.2017.04.012

TY - JOUR

T1 - A prospective international Aspergillus terreus survey

T2 - an EFISG, ISHAM and ECMM joint study

AU - Risslegger, B.

AU - Zoran, T.

AU - Lackner, M.

AU - Aigner, M.

AU - Sánchez-Reus, F.

AU - Rezusta, A.

AU - Chowdhary, A.

AU - Taj-Aldeen, S. J.

AU - Arendrup, M. C.

AU - Oliveri, S.

AU - Kontoyiannis, D. P.

AU - Alastruey-Izquierdo, A.

AU - Lagrou, K.

AU - Lo Cascio, G.

AU - Meis, J. F.

AU - Buzina, W.

AU - Farina, C.

AU - Drogari-Apiranthitou, M.

AU - Grancini, A.

AU - Tortorano, A. M.

AU - Willinger, B.

AU - Hamprecht, A.

AU - Johnson, E.

AU - Klingspor, L.

AU - Arsic-Arsenijevic, V.

AU - Cornely, O. A.

AU - Meletiadis, J.

AU - Prammer, W.

AU - Tullio, V.

AU - Vehreschild, J. J.

AU - Trovato, L.

AU - Lewis, R. E.

AU - Segal, E.

AU - Rath, P. M.

AU - Hamal, P.

AU - Rodriguez-Iglesias, M.

AU - Roilides, E.

AU - Arikan-Akdagli, S.

AU - Chakrabarti, A.

AU - Colombo, A. L.

AU - Fernández, M. S.

AU - Martin-Gomez, M. T.

AU - Badali, H.

AU - Petrikkos, G.

AU - Klimko, N.

AU - Heimann, S. M.

AU - Houbraken, J.

AU - Uzun, O.

AU - Edlinger, M.

AU - Fuente, S. de la

AU - Lass-Flörl, C.

PY - 2017/10

Y1 - 2017/10

N2 - Objectives A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods A total of 370 cases from 21 countries were evaluated. Results The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.

AB - Objectives A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods A total of 370 cases from 21 countries were evaluated. Results The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.

KW - Amphotericin B

KW - Aspergillosis

KW - Aspergillus terreus

KW - Crytic species

KW - In vitrosusceptibility

UR - http://www.scopus.com/inward/record.url?scp=85021237872&partnerID=8YFLogxK

U2 - 10.1016/j.cmi.2017.04.012

DO - 10.1016/j.cmi.2017.04.012

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:85021237872

SN - 1198-743X

VL - 23

SP - 776.e1-776.e5

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 10

ER -

A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

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Keywords

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