TY - JOUR
T1 - A prospective evaluation of thallium-201 single photon emission computerized tomography for brain tumor burden
AU - Lorberboym, Mordechai
AU - Baram, Jacob
AU - Feibel, Meir
AU - Hercbergs, Aleck
AU - Lieberman, Lionel
PY - 1995/4/30
Y1 - 1995/4/30
N2 - Purpose: The follow-up of patients with malignant brain tumors after surgery, radiation, and/or chemotherapy has been inadequate for evaluating brain tumor burden using computerized tomography (CT) or magnetic resonance imaging (MRI). Thallium-201 has been shown to concentrate in viable tumor, and TI-201 single photon emission computerized tomography (SPECT) imaging can identify tumor burden more accurately than CT. Methods and Materials: Thirty-one patients with glioblastoma and three patients with low grade astrocytoma were studied with TI-201 SPECT. Histologic diagnosis was obtained in all patients by biopsy and all patients had CT scans within 2 weeks of the SPECT study. Seventeen patients were followed with one or more SPECT and CT evaluations. Results: Single photon emission computerized tomography studies, after surgery, radiotherapy, and/or chemotherapy, were more accurate than CT in identifying progression or regression of disease. Twenty-three patients had evidence of disease and 11 patients had no evidence of recurrent disease in the initial TI-201 SPECT study following therapy. Computerized tomography identified 20 of the 23 patients with disease and 6 of 11 patients with no recurrent disease. Follow-up with TI-201 SPECT in 17 patients suggested progression of disease in 9 patients, while CT showed progression in only 3 patients. Clinical examinations and repeat CT studies confirmed the accuracy of TI-201 SPECT images. Conclusion: We found TI-201 SPECT more accurate than CT scans in a prospective evaluation of 34 patients with brain tumor. Follow-up studies with both TI-201 SPECT and CT imaging in 17 patients demonstrated that sPECT was more reliable than CT in identifying progression, improvement, or no change in brain tumor burden.
AB - Purpose: The follow-up of patients with malignant brain tumors after surgery, radiation, and/or chemotherapy has been inadequate for evaluating brain tumor burden using computerized tomography (CT) or magnetic resonance imaging (MRI). Thallium-201 has been shown to concentrate in viable tumor, and TI-201 single photon emission computerized tomography (SPECT) imaging can identify tumor burden more accurately than CT. Methods and Materials: Thirty-one patients with glioblastoma and three patients with low grade astrocytoma were studied with TI-201 SPECT. Histologic diagnosis was obtained in all patients by biopsy and all patients had CT scans within 2 weeks of the SPECT study. Seventeen patients were followed with one or more SPECT and CT evaluations. Results: Single photon emission computerized tomography studies, after surgery, radiotherapy, and/or chemotherapy, were more accurate than CT in identifying progression or regression of disease. Twenty-three patients had evidence of disease and 11 patients had no evidence of recurrent disease in the initial TI-201 SPECT study following therapy. Computerized tomography identified 20 of the 23 patients with disease and 6 of 11 patients with no recurrent disease. Follow-up with TI-201 SPECT in 17 patients suggested progression of disease in 9 patients, while CT showed progression in only 3 patients. Clinical examinations and repeat CT studies confirmed the accuracy of TI-201 SPECT images. Conclusion: We found TI-201 SPECT more accurate than CT scans in a prospective evaluation of 34 patients with brain tumor. Follow-up studies with both TI-201 SPECT and CT imaging in 17 patients demonstrated that sPECT was more reliable than CT in identifying progression, improvement, or no change in brain tumor burden.
KW - Astrocytoma
KW - Brain neoplasms
KW - CT
KW - Glioblastoma
KW - Radionuclide diagnosis
KW - Thallium-201 SPECT
UR - http://www.scopus.com/inward/record.url?scp=0028910512&partnerID=8YFLogxK
U2 - 10.1016/0360-3016(95)00580-R
DO - 10.1016/0360-3016(95)00580-R
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C2 - 7721624
AN - SCOPUS:0028910512
SN - 0360-3016
VL - 32
SP - 249
EP - 254
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 1
ER -
