A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients

Y. Bersudsky, M. Kotler, M. Shifrin, R. H. Belmaker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Forskolin is a unique activator of adenylate cyclase that bypasses membrane receptors and directly raises levels of the second messenger cyclic AMP. Depressed patients and schizophrenic patients with negative symptoms have been reported to have reduced cyclic AMP levels. In the first study of forskolin in psychiatry, we gave iv forskolin in a 75 minute infusion to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients.

Original languageEnglish
Pages (from-to)1463-1467
Number of pages5
JournalJournal of Neural Transmission
Volume103
Issue number12
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Cyclic AMP
  • Depression
  • Forskolin
  • Schizophrenia

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