TY - JOUR
T1 - A possible role for 15-lipoxygenase in atherogenesis
AU - Harats, Dror
AU - Mulkins, Mary A.
AU - Sigal, Elliott
N1 - Funding Information:
The authors thank Craig Laughton and Chakk Ramesha for helpful discussions and for help with the figures. We gratefully acknowledge Drs. Daniel Steinberg and Seppo YlBHerttuala for Figure 3. D.H. was funded by a grant from the Council for Tobacco Research and NM- Fogarty International Fellowship grant 5 F05 TW04804-02.
PY - 1995
Y1 - 1995
N2 - It is well accepted that high levels of low-density lipoprotein (LDL) cholesterol in the plasma are associated with increased risk of atherosclerosis. The cellular and molecular mechanisms linking the two however, have not been fully resolved. One of the processes involved in atherogensis that has been intensively studied in this regard is the oxidation of LDL. Oxidation may convert LDL into an atherogenic form, which incites an inflammatory and proliferative response characteristic of the atherosclerotic lesion. One of the potential mediators in this process is the lipid peroxidating enzyme 15-lipoxygenase, which has been shown to be induced in the atherosclerotic lesion and is capable of oxidizing LDL. In this article, we review the motivation for looking at mechanisms of LDL oxidation and the proposed involvement of 15-lipoxygenase in the pathogenesis of the disease.
AB - It is well accepted that high levels of low-density lipoprotein (LDL) cholesterol in the plasma are associated with increased risk of atherosclerosis. The cellular and molecular mechanisms linking the two however, have not been fully resolved. One of the processes involved in atherogensis that has been intensively studied in this regard is the oxidation of LDL. Oxidation may convert LDL into an atherogenic form, which incites an inflammatory and proliferative response characteristic of the atherosclerotic lesion. One of the potential mediators in this process is the lipid peroxidating enzyme 15-lipoxygenase, which has been shown to be induced in the atherosclerotic lesion and is capable of oxidizing LDL. In this article, we review the motivation for looking at mechanisms of LDL oxidation and the proposed involvement of 15-lipoxygenase in the pathogenesis of the disease.
UR - http://www.scopus.com/inward/record.url?scp=0028930887&partnerID=8YFLogxK
U2 - 10.1016/1050-1738(94)00029-U
DO - 10.1016/1050-1738(94)00029-U
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AN - SCOPUS:0028930887
SN - 1050-1738
VL - 5
SP - 29
EP - 36
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 1
ER -