A possible mechanism for phenol-induced pemphigus.

Sarah Brenner, Vincenzo Ruocco, Eleonora Ruocco, Avigdor Srebrnik, Ilan Goldberg

Research output: Contribution to journalReview articlepeer-review

Abstract

A possible mechanism for phenol-induced pemphigus lesions in genetically predisposed individuals is proposed that accounts for in vitro observations and cases of biochemical acantholysis, as well as the in vivo acantholysis in pemphigus induced by phenols. The mechanism involves the induction of interleukin-1a and tumor necrosis factor-a release by keratinocytes. These cytokines in turn have been shown to be involved in the regulation and synthesis of complement and proteases like plasminogen activator, which have been implicated in the pathogenesis of acantholysis in pemphigus vulgaris.

Original languageEnglish
Pages (from-to)25-26; quiz 27-28
JournalSkinmed
Volume5
Issue number1
DOIs
StatePublished - 2006

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