A possible genetic factor in the pathogenesis of ovarian dermoid cysts

B. Caspi, L. Lerner-Geva, M. Dahan, A. Chetrit, B. Modan, Z. Hagay, Z. Appelman

Research output: Contribution to journalArticlepeer-review

Abstract

This study was undertaken in order to evaluate a possible genetic influence on the pathogenesis of ovarian dermoid cysts. We have performed a case-control study comparing the prevalence of a history of dermoid cysts in first-degree relatives of women with dermoid cysts and among first-degree relatives of women without dermoid cysts. The study group included 285 women with an established diagnosis of ovarian dermoid cysts. The control group included 378 women with sonographically normal ovaries. To assess the relationship between a first-degree family history of dermoid cysts and the diagnosis of ovarian dermoid cysts, a multivariate stepwise logistic regression model was applied. In 28 families of the study group (9.8%), a dermoid cyst was found in at least 1 first-degree relative as compared with only eight families (2%) among the controls (adjusted odds ratio -5.60; 95% CI 2.24-14.2). The data suggest a genetic predisposition towards dermoid cysts which merits further exploration.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume56
Issue number4
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Cystic teratoma
  • Dermoid cysts
  • Genetics, ovarian dermoid cysts
  • Inheritance, dermoid cysts

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