A phase II study of combined administration of dacarbazine and carboplatin with home therapy of recombinant interleukin-2 and interferon-α2a in patients with advanced malignant melanoma

Han G. Ron*, Yair Mordish, Avi Eisenthal, Yehuda Skornick, Moshe J. Inbar, Samario Chaitchik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Chemotherapy and interleukin-2 (IL-2) and/or interferon α (IFNα) produce objective responses in a proportion of patients with advanced malignant melanoma. The duration of response to chemotherapy is usually less than 4 months, and immunotherapy has resulted in longlasting remissions in a small number of patients with metastatic melanoma. The current study was conducted to improve the antitumor efficacy and the interactions between recombinant (r) IL-2, rIFNα2a and chemotherapy. A total of 16 evaluable patients with metastatic malignant melanoma were entered into a phase-II study designed to assess the response rate and therapeutic efficacy of dacarbazine and carboplatin followed by rIL-2 and rIFNα2a. Patients received 750 mg/m2 dacarbazine with 400 mg/m2 carboplatin each by intravenous bolus on days 1 and 22. Recombinant IL-2 and IFNα2a were administered on an outpatient basis (home therapy) subcutaneously for 6 consecutive weeks: 4.8×106 IU/m2 rIL-2 daily, 5 days a week; 6.0×106 IU/m2 rIFNα2a thrice weekly. There were responses in 6 of the 16 enrolled patients with an overall response rate of 37.5% (95% confidence interval: 14%-61%). All responding patients had partial responses. The median survival time of the responding patients was significantly better than that of patients with progressive and stable disease (P=0.03). The median duration of response was 11 months (range 2-24 months). Responses in lung, liver, soft tissue and lymph-node sites were noted.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalCancer Immunology, Immunotherapy
Volume38
Issue number6
DOIs
StatePublished - Nov 1994

Keywords

  • Carboplatin
  • Chemotherapy
  • Dacarbazine (DTIC)
  • Immunotherapy
  • Interleukin-2
  • Metastatic malignant melanoma
  • Recombinant interferon

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