TY - JOUR
T1 - A perspective on muscle phenotyping in musculoskeletal research
AU - Co-authors
AU - Foessl, Ines
AU - Ackert-Bicknell, Cheryl L.
AU - Kague, Erika
AU - Laskou, Faidra
AU - Jakob, Franz
AU - Karasik, David
AU - Obermayer-Pietsch, Barbara
AU - Alonso, Nerea
AU - Bjørnerem, Åshild
AU - Brandi, Maria Luisa
AU - Busse, Björn
AU - Calado, Ângelo
AU - Cebi, Alper Han
AU - Christou, Maria
AU - Curran, Kathleen M.
AU - Hald, Jannie Dahl
AU - Semeraro, Maria Donatella
AU - Douni, Eleni
AU - Duncan, Emma L.
AU - Duran, Ivan
AU - Formosa, Melissa M.
AU - Gabet, Yankel
AU - Ghatan, Samuel
AU - Gkitakou, Artemis
AU - Hassler, Eva Maria
AU - Högler, Wolfgang
AU - Heino, Terhi J.
AU - Hendrickx, Gretl
AU - Khashayar, Patricia
AU - Kiel, Douglas P.
AU - Koromani, Fjorda
AU - Langdahl, Bente
AU - Lopes, Philippe
AU - Mäkitie, Outi
AU - Maurizi, Antonio
AU - Medina-Gomez, Carolina
AU - Ntzani, Evangelia
AU - Ohlsson, Claes
AU - Prijatelj, Vid
AU - Rabionet, Raquel
AU - Reppe, Sjur
AU - Rivadeneira, Fernando
AU - Roshchupkin, Gennady
AU - Sharma, Neha
AU - Søe, Kent
AU - Styrkarsdottir, Unnur
AU - Szulc, Pavel
AU - Teti, Anna
AU - Tobias, Jon
AU - Valjevac, Amina
N1 - Publisher Copyright:
© 2024
PY - 2024/6
Y1 - 2024/6
N2 - Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.
AB - Musculoskeletal research should synergistically investigate bone and muscle to inform approaches for maintaining mobility and to avoid bone fractures. The relationship between sarcopenia and osteoporosis, integrated in the term ‘osteosarcopenia’, is underscored by the close association shown between these two conditions in many studies, whereby one entity emerges as a predictor of the other. In a recent workshop of Working Group (WG) 2 of the EU Cooperation in Science and Technology (COST) Action ‘Genomics of MusculoSkeletal traits Translational Network’ (GEMSTONE) consortium (CA18139), muscle characterization was highlighted as being important, but currently under-recognized in the musculoskeletal field. Here, we summarize the opinions of the Consortium and research questions around translational and clinical musculoskeletal research, discussing muscle phenotyping in human experimental research and in two animal models: zebrafish and mouse.
KW - animal models
KW - muscle
KW - musculoskeletal phenotyping
KW - sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85189075377&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2024.01.004
DO - 10.1016/j.tem.2024.01.004
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C2 - 38553405
AN - SCOPUS:85189075377
SN - 1043-2760
VL - 35
SP - 478
EP - 489
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 6
ER -