A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice

Liana Beni-Adani, Illana Gozes, Yoram Cohen, Yaniv Assaf, Ruth A. Steingart, Douglas E. Brenneman, Oded Eizenberg, Victoria Trembolver, Esther Shohami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Brain injury induces disruption of the blood-brain barrier, edema, and release of autodestructive factors that produce delayed neuronal damage. NAPSVIPQ (NAP), a femtomolar-acting peptide, is shown to be neuroprotective in a mouse model of closed head injury. NAP injection after injury reduced mortality and facilitated neurobehavioral recovery (P < 0.005). Edema was reduced by 70% in the NAP-treated mice (P <0.01). Furthermore, in vivo magnetic resonance imaging demonstrated significant brain-tissue recovery in the NAP-treated animals. NAP treatment decreased tumor necrosis factor-α levels in the injured brain and was shown to protect pheochromocytoma (PC12 cells) against tumor necrosis factor-α-induced toxicity. Thus, NAP provides significant amelioration from the complex array of injuries elicited by head trauma.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume296
Issue number1
StatePublished - 2001

Funding

FundersFunder number
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentZ01HD000047

    Fingerprint

    Dive into the research topics of 'A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice'. Together they form a unique fingerprint.

    Cite this