@article{3a5ce768493940ae988b014fc6981e9c,
title = "A NusG-like transcription anti-terminator is involved in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus",
abstract = "The antibiotic TA of Myxococcus xanthus is synthesized through a type I polyketide synthase mechanism. Previous studies have indicated that several genes essential for TA production are clustered within a 40-kb region and are transcriptionally co-regulated. In this study, we report the genetic analysis of the first gene in the TA gene cluster, identified as a NusG-like transcription anti-terminator. Functional analysis of this NusG-like anti-terminator gene by specific gene disruption confirms that it is essential for TA production but not for normal growth and development. Copyright (C) 1999 Elsevier Science B.V.",
keywords = "Antibiotic biosynthesis, Myxococcus xanthus, NusG, Polyketide, Transcription anti-termination, Type I polyketide synthase",
author = "Yossi Paitan and Elisha Orr and Ron, {Eliora Z.} and Eugene Rosenberg",
note = "Funding Information: We thank Dr. Steven G. Sedgwick for providing the tagged Tn 1000 system. This work was supported in part by the Pasha Gol Chair for Applied Microbiology (E.R.), the Morris and Manja Leigh Chair for Biophysics and Biotechnology (E.Z.R.), a FEMS Research fellowship awarded to Y.P., Cancer Research Campaign (SP1937/0301) and Wellcome Trust (038060/Z/93/Z) grants to E.O. ",
year = "1999",
month = jan,
day = "1",
doi = "10.1016/S0378-1097(98)00542-4",
language = "אנגלית",
volume = "170",
pages = "221--227",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Oxford University Press",
number = "1",
}