A novel prostaglandin is the major product of arachidonic acid metabolism in rabbit heart

P. C. Isakson, A. Raz, S. E. Denny, E. Pure, P. Needleman

Research output: Contribution to journalArticlepeer-review

Abstract

The prostaglandins (PGs) released from the heart have generally been characterized as resembling PGE by bioassay techniques. The major PG formed from [ 14C]arachidonate (C(20.:4)) by the isolated perfused rabbit heart has chromatographic mobility similar to that of PGE 2 in most solvent systems. However, additional analysis of this radioactive 'PGE' peak suggests that 2 substances are formed by the heart and migrate like PGE 2: 1 has chemical properties similar to those of authentic PGE 2 and the other is a novel PG. The unknown compound is the major PG formed by the heart from either exogenous arachidonate or hormonal stimulation of PG biosynthesis. The novel PG produced by the heart may be identical with either 6(9) oxy PGF or 6 keto PGF 1(α).

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume74
Issue number1
DOIs
StatePublished - 1977
Externally publishedYes

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