TY - GEN
T1 - A novel probabilistic methodology for eQTL analysis of signaling networks
AU - Wilentzik, Roni
AU - Gat-Viks, Irit
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - Quantitative trait loci (QTL) studies of common diseases have been spectacularly successful in the last few years and became routine in medical genetics. These studies typically identify genetic variants (QTLs) that are associated with organismal phenotypes, such as susceptibility to disease. Genetic variants can underlie the abundance of gene transcripts, forming ‘expression QTLs’ (eQTLs; [1]). Despite the biomedical importance of understanding how such loci truly affect quantitative traits, several questions remain unsolved: What is the particular mechanism by which a genomic locus affects a quantitative trait? Which specific signaling pathways are responsible for propagating the inherited variation from an eQTL to the gene expression or physiological trait? On which component within such a pathway does the genetic variant act? While it is clear that genetic variants play a critical role in quantitative traits, it is still not fully understood how such variants lead to the inherited variation.
AB - Quantitative trait loci (QTL) studies of common diseases have been spectacularly successful in the last few years and became routine in medical genetics. These studies typically identify genetic variants (QTLs) that are associated with organismal phenotypes, such as susceptibility to disease. Genetic variants can underlie the abundance of gene transcripts, forming ‘expression QTLs’ (eQTLs; [1]). Despite the biomedical importance of understanding how such loci truly affect quantitative traits, several questions remain unsolved: What is the particular mechanism by which a genomic locus affects a quantitative trait? Which specific signaling pathways are responsible for propagating the inherited variation from an eQTL to the gene expression or physiological trait? On which component within such a pathway does the genetic variant act? While it is clear that genetic variants play a critical role in quantitative traits, it is still not fully understood how such variants lead to the inherited variation.
UR - http://www.scopus.com/inward/record.url?scp=84926357577&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-16706-0_34
DO - 10.1007/978-3-319-16706-0_34
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AN - SCOPUS:84926357577
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 338
EP - 339
BT - Research in Computational Molecular Biology - 19th Annual International Conference, RECOMB 2015, Proceedings
A2 - Przytycka, Teresa M.
PB - Springer Verlag
T2 - 19th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2015
Y2 - 12 April 2015 through 15 April 2015
ER -