TY - JOUR
T1 - A novel method for liver repopulation
T2 - Heterografting of micro-liver slices in a rat model
AU - Gur, Eyal
AU - Deckel, Roi
AU - Zvibel, Isabel
AU - Brazovsky, Eli
AU - Kariv, Revital
AU - Brill, Shlomo
AU - Halpern, Zamir
AU - Oren, Ran
N1 - Funding Information:
From *The Microsurgery Unit, Department of Plastic Surgery; †Liver Unit, Gastroenterology Institute; and ‡Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. Supported in part by a grant from the Binational Science Foundation (R.O. and David Shafritz). Address reprint requests to Ran Oren, MD, The Liver Unit, Gastroenterology Institute, Tel Aviv Sourasky Medical Center, Weizmann 6, Tel Aviv 64239, Israel. Telephone: 972-3-697-3984; FAX: 972-3-697-4622; E-mail: [email protected] Copyright © 2003 by the American Association for the Study of Liver Diseases 1527-6465/03/0904-0016$30.00/0 doi:10.1053/jlts.2003.50056
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The field of hepatocyte transplantation is developing, with encouraging results. However, current approaches are still unsuitable for human cell therapy, and safer and more applicable methods need to be developed. We recently successfully transplanted pieces of liver tissue (slices), cut from a wild-type Fischer 344 dipeptidyl peptidase IV (DPP IV)-positive rat and introduced into the liver of a DPP IV-deficient Fischer 344 rat. One month after the procedure, positive DPP IV enzymatic activity was detected in transplanted liver slices. These results suggest that transplantation of tissue slices is feasible and safe and could serve as a promising alternative to hepatocyte transplantation.
AB - The field of hepatocyte transplantation is developing, with encouraging results. However, current approaches are still unsuitable for human cell therapy, and safer and more applicable methods need to be developed. We recently successfully transplanted pieces of liver tissue (slices), cut from a wild-type Fischer 344 dipeptidyl peptidase IV (DPP IV)-positive rat and introduced into the liver of a DPP IV-deficient Fischer 344 rat. One month after the procedure, positive DPP IV enzymatic activity was detected in transplanted liver slices. These results suggest that transplantation of tissue slices is feasible and safe and could serve as a promising alternative to hepatocyte transplantation.
UR - http://www.scopus.com/inward/record.url?scp=0037387865&partnerID=8YFLogxK
U2 - 10.1053/jlts.2003.50056
DO - 10.1053/jlts.2003.50056
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C2 - 12682896
AN - SCOPUS:0037387865
SN - 1527-6465
VL - 9
SP - 421
EP - 424
JO - Liver Transplantation
JF - Liver Transplantation
IS - 4
ER -