A novel design of injectable porous hydrogels with in situ pore formation

Ortal Yom-Tov, Lena Neufeld, Dror Seliktar, Havazelet Bianco-Peled*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The use of injectable porous hydrogels is of great interest in biomedical applications due to their excellent permeability and ease of integration into sites of surgical intervention. By implementing a method that enables the formation in situ of pores with controllable porosity and pore size, it is possible to synthesize bioactive hydrogels that are tailor-made for specific biomedical applications. An emulsion-templating technique was used to encapsulate oil droplets, which are subsequently leached out of the hydrogel to create the porous structure. Pore size and porosity were manipulated by changing oil-to-water ratios and the surfactant concentrations. Highly swellable porous hydrogels were obtained with control over mechanical strength and diffusive properties. The relationship between porosity, pore size, and the hydrogel's physical and mechanical characteristics was analyzed, and the potential of this material as a protein drug delivery system was demonstrated.

Original languageEnglish
Pages (from-to)4236-4246
Number of pages11
JournalActa Biomaterialia
Volume10
Issue number10
DOIs
StatePublished - 1 Oct 2014
Externally publishedYes

Keywords

  • Biomaterials
  • Emulsion-templating
  • Hydrogels
  • Pore size
  • Porosity

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