TY - JOUR
T1 - A novel cardiotoxic polypeptide from the venom of Atractaspis engaddensis (burrowing asp)
T2 - Cardiac effects in mice and isolated rat and human heart preparations
AU - Wollberg, Z.
AU - Shabo-Shina, R.
AU - Intrator, N.
AU - Bdolah, A.
AU - Kochva, E.
AU - Shavit, G.
AU - Oron, Y.
AU - Vidne, B. A.
AU - Gitter, S.
N1 - Funding Information:
Acknowledgements - We are indebted to Mrs S. KINAMON, Mrs M . WOLLBERG, Mr H . STEeNBERG and Mr G . BERNADsKY for assistance; to the late Professor N . NEUFELD and Professors Y . LAss, E . KAPLINsKY and Dr G . ScHREiEER for comments and Ms N. PAz for help in preparation of the manuscript . This research was supported in part by a grant of the Tel Aviv University Basic Research Fund .
PY - 1988
Y1 - 1988
N2 - A novel cardiotoxic polypeptide from the venom of Atractaspis engaddensis (burrowing asp): cardiac effects in mice and isolated rat and human heart preparations. Toxicon 26, 525 - 534, 1988. - A new cardiotoxic polypeptide isolated from the venom of the snake Atractaspis engaddensis has an LD50 of 15 μg/kg body weight in white mice. Intravenous administration in mice of lethal doses of the toxin causes, within seconds, marked changes in the ECG, consisting primarily of a transient slope elevation of the S-T segment, a temporary diminution of the S-wave and an increase in the amplitudes of the R- and T-waves. Concomitantly, and apparently unrelated to these changes, a severe A-V block develops and leads to complete cardiac arrest within a few min. Studies with rat and human isolated heart preparations showed that the toxin exerts a powerful coronary vasoconstriction (rats), and positive inotropic effects (rats and humans).
AB - A novel cardiotoxic polypeptide from the venom of Atractaspis engaddensis (burrowing asp): cardiac effects in mice and isolated rat and human heart preparations. Toxicon 26, 525 - 534, 1988. - A new cardiotoxic polypeptide isolated from the venom of the snake Atractaspis engaddensis has an LD50 of 15 μg/kg body weight in white mice. Intravenous administration in mice of lethal doses of the toxin causes, within seconds, marked changes in the ECG, consisting primarily of a transient slope elevation of the S-T segment, a temporary diminution of the S-wave and an increase in the amplitudes of the R- and T-waves. Concomitantly, and apparently unrelated to these changes, a severe A-V block develops and leads to complete cardiac arrest within a few min. Studies with rat and human isolated heart preparations showed that the toxin exerts a powerful coronary vasoconstriction (rats), and positive inotropic effects (rats and humans).
UR - http://www.scopus.com/inward/record.url?scp=0023911930&partnerID=8YFLogxK
U2 - 10.1016/0041-0101(88)90232-2
DO - 10.1016/0041-0101(88)90232-2
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AN - SCOPUS:0023911930
SN - 0041-0101
VL - 26
SP - 525
EP - 534
JO - Toxicon
JF - Toxicon
IS - 6
ER -
