A new transorbital surgical approach to the rabbit's optic nerve

A. Solomon, M. Belkin, M. Hadani, A. Harel, I. Rachailovich, V. Lavie, M. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

This work describes a surgical approach which establishes the rabbit's visual system as an experimental model for studying CNS regeneration. Using this model, the optic nerve, its cell bodies, and the axons, are easily accessible through an orbital approach, without the need for craniotomy and brain retraction. This surgical approach allows transplantation and 'wrap around' implantations of nerve segments from xenogeneic and syngeneic systems and diffusible substances derived from them, respectively. Furthermore, it enables studies aimed at determining deficiencies in mammalian CNS and investigating methods of augmentating mammalian CNS regeneration.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalJournal of Neuroscience Methods
Volume12
Issue number3
DOIs
StatePublished - Jan 1985

Keywords

  • animal model
  • central nervous system regeneration
  • optic nerve
  • orbital surgery
  • transplantation
  • xenograft

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