A new transmissible AIDS-like disease in mice induced by alloimmune stimuli

Victor S. Ter-Grigorov, Oleg Krifuks, Eugenia Liubashevsky, Abraham Nyska, Zeev Trainin, Vladimir Toder

Research output: Contribution to journalArticlepeer-review


The search for a suitable and reliable animal model for human AIDS that is easy to use on a large scale continues. Here we describe a new condition in mice that closely resembles human AIDS, namely, chronic lymphoproliferation with dramatic depletion of CD4-positive cells, progressive impairment of the immune responses, and Kaposi's sarcoma-like tumors or terminal B-lymphomas. The AIDS-like disease was primarily induced by mating BALB/c female mice to C57BL/6 males during a 1-year period (7-10 allogeneic pregnancies) followed by immunization with paternal lymphocytes. The disease is sexually and vertically transmissible, transferrable by cell-free plasma and is associated with autoimmune reactions to major histocompatibility complex antigens and CD4 cells. We hope that this becomes a model for studying the mechanisms of AIDS immunopathogenesis and immune-based treatment approaches.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalNature Medicine
Issue number1
StatePublished - 1997


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