A new mutation in the HEXA gene associated with a spinal muscular atrophy phenotype

R. Navon*, R. Khosravi, T. Korczyn, M. Masson, S. Sonnino, M. Fardeau, B. Eymard, M. Lefevre, J. C. Turpin, P. Rondot, N. Baumann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We describe two adult siblings who had had mild GM2 gangliosidosis since childhood. They presented with spinal muscular atrophy and dysarthria, and one sibling also had mental disturbances. Laboratory studies established the diagnosis of the B1 variant of GM2 gangliosidosis, because the hexosaminidase (Hex) A deficiency was not present upon testing with the unsulfated synthetic substrate 4-methylumbelliferyl N-acetylglucosaminide. HEXA gene analysis proved that the patients are compound heterozygotes for the previously identified G533→A mutation and for a new mutation, G1171→A, at exon 11. This new mutation affects a conserved amino acid and results in a Val→Met substitution at position 391 of the HEXA gene. Full sequence of the α-subunit cDNA of Hex A revealed no other mutation. Assays for Hex A activities in patients suspected of having GM2 gangliosidosis should be performed with the sulfated substrate 4-methylumbelliferyl N- acetylglucosamine 6-sulfate.

Original languageEnglish
Pages (from-to)539-543
Number of pages5
Issue number3 I
StatePublished - Mar 1995


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