A new efficient deprotection of azines, hydrazones and oximes. An excellent route for exchanging oxygen isotopes in carbonyls

Mira Carmeli, Shlomo Rozen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Carbonyls, protected as azines or other C=N derivatives can be deprotected by HOF·CH3CN in seconds to the corresponding ketone or aldehyde in very good yields. This reaction also offers a very efficient route for replacing the oxygen atom of most carbonyls with any other oxygen isotope, for example, [18]O.

Original languageEnglish
Pages (from-to)763-766
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number5
DOIs
StatePublished - 30 Jan 2006

Funding

FundersFunder number
Israel Science Foundation

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