A new concept of cotreatment with human growth hormone and menotropins in ovulation induction protocols

R. Orvieto, R. Homburg, J. Farhi, I. Bar-Hava, Z. Ben-Rafael

Research output: Contribution to journalArticlepeer-review

Abstract

Follicular development in the primordial and preantral stages is almost completely independent of gonadotrophins or steroids and is mainly dependent on growth factors and local regulators. Since human growth hormone (hGH) was found to facilitate ovarian response to gonadotrophin stimulation, we hypothesized that the administration of hGH in an hypogonadotrophic state and prior to ovarian stimulation with menotropins, may initiate or facilitate the propagation of the primordial and preantral follicles to the gonadotrophin-dependent stages. We suggest that treatment with hGH prior to menotropin administration may be useful to improve results for poor responders to gonadotrophins.

Original languageEnglish
Pages (from-to)413-415
Number of pages3
JournalMedical Hypotheses
Volume49
Issue number5
DOIs
StatePublished - Nov 1997

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