Abstract
[Equation presented] The clinically important antibiotic neomycin B was modified at position C5″ by adding one extra sugar ring in the β-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.
Original language | English |
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Pages (from-to) | 3575-3578 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 5 |
Issue number | 20 |
DOIs | |
State | Published - 2 Oct 2003 |
Externally published | Yes |