A new class of branched aminoglycosides: Pseudo-pentasaccharide derivatives of neomycin B

Micha Fridman; Valery Belakhov; Sima Yaron; Timor Baasov

doi:10.1021/ol035213i

A new class of branched aminoglycosides: Pseudo-pentasaccharide derivatives of neomycin B

Micha Fridman, Valery Belakhov, Sima Yaron, Timor Baasov

Research output: Contribution to journal › Article › peer-review

Abstract

[Equation presented] The clinically important antibiotic neomycin B was modified at position C5″ by adding one extra sugar ring in the β-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.

Original language	English
Pages (from-to)	3575-3578
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	20
DOIs	https://doi.org/10.1021/ol035213i
State	Published - 2 Oct 2003
Externally published	Yes

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10.1021/ol035213i

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title = "A new class of branched aminoglycosides: Pseudo-pentasaccharide derivatives of neomycin B",

abstract = "[Equation presented] The clinically important antibiotic neomycin B was modified at position C5″ by adding one extra sugar ring in the β-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.",

author = "Micha Fridman and Valery Belakhov and Sima Yaron and Timor Baasov",

year = "2003",

month = oct,

day = "2",

doi = "10.1021/ol035213i",

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AU - Fridman, Micha

AU - Belakhov, Valery

AU - Yaron, Sima

AU - Baasov, Timor

PY - 2003/10/2

Y1 - 2003/10/2

N2 - [Equation presented] The clinically important antibiotic neomycin B was modified at position C5″ by adding one extra sugar ring in the β-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.

AB - [Equation presented] The clinically important antibiotic neomycin B was modified at position C5″ by adding one extra sugar ring in the β-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.

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JO - Organic Letters

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A new class of branched aminoglycosides: Pseudo-pentasaccharide derivatives of neomycin B

Abstract

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