A new class of branched aminoglycosides: Pseudo-pentasaccharide derivatives of neomycin B

Micha Fridman, Valery Belakhov, Sima Yaron, Timor Baasov

Research output: Contribution to journalArticlepeer-review

Abstract

[Equation presented] The clinically important antibiotic neomycin B was modified at position C5″ by adding one extra sugar ring in the β-configuration, and the observed pseudo-pentasaccharides were tested against various bacterial strains, including pathogenic and resistant strains. The designed antibiotics show antibacterial activity superior to that of neomycin B against pathogenic and resistant bacterial strains.

Original languageEnglish
Pages (from-to)3575-3578
Number of pages4
JournalOrganic Letters
Volume5
Issue number20
DOIs
StatePublished - 2 Oct 2003
Externally publishedYes

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