A neural model of demyelination of the mouse spinal cord

Biljana Petreska, Yossi Yovel

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper presents a neural network model of demyelination of the mouse motor pathways, coupled to a central pattern generation (CPG) model for quadruped walking. Demyelination is the degradation of the myelin layer covering the axons which can be caused by several neurodegenerative autoimmune diseases such as multiple sclerosis. We use this model - to our knowledge first of its kind - to investigate the locomotion deficits that appear following demyelination of axons in the spinal cord. Our model meets several physiological and behavioral results and predicts that whereas locomotion can still occur at high percentages of demyelination damage, the distribution and location of the lesion are the most critical factors for the locomotor performance.

Original languageEnglish
Title of host publication2008 International Joint Conference on Neural Networks, IJCNN 2008
Pages2538-2544
Number of pages7
DOIs
StatePublished - 2008
Externally publishedYes
Event2008 International Joint Conference on Neural Networks, IJCNN 2008 - Hong Kong, China
Duration: 1 Jun 20088 Jun 2008

Publication series

NameProceedings of the International Joint Conference on Neural Networks

Conference

Conference2008 International Joint Conference on Neural Networks, IJCNN 2008
Country/TerritoryChina
CityHong Kong
Period1/06/088/06/08

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