A neural model of demyelination of the mouse spinal cord

Biljana Petreska; Yossi Yovel

doi:10.1109/IJCNN.2008.4634153

A neural model of demyelination of the mouse spinal cord

Biljana Petreska^*, Yossi Yovel

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This paper presents a neural network model of demyelination of the mouse motor pathways, coupled to a central pattern generation (CPG) model for quadruped walking. Demyelination is the degradation of the myelin layer covering the axons which can be caused by several neurodegenerative autoimmune diseases such as multiple sclerosis. We use this model - to our knowledge first of its kind - to investigate the locomotion deficits that appear following demyelination of axons in the spinal cord. Our model meets several physiological and behavioral results and predicts that whereas locomotion can still occur at high percentages of demyelination damage, the distribution and location of the lesion are the most critical factors for the locomotor performance.

Original language	English
Title of host publication	2008 International Joint Conference on Neural Networks, IJCNN 2008
Pages	2538-2544
Number of pages	7
DOIs	https://doi.org/10.1109/IJCNN.2008.4634153
State	Published - 2008
Externally published	Yes
Event	2008 International Joint Conference on Neural Networks, IJCNN 2008 - Hong Kong, China Duration: 1 Jun 2008 → 8 Jun 2008

Publication series

Name	Proceedings of the International Joint Conference on Neural Networks

Conference

Conference	2008 International Joint Conference on Neural Networks, IJCNN 2008
Country/Territory	China
City	Hong Kong
Period	1/06/08 → 8/06/08

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10.1109/IJCNN.2008.4634153

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title = "A neural model of demyelination of the mouse spinal cord",

abstract = "This paper presents a neural network model of demyelination of the mouse motor pathways, coupled to a central pattern generation (CPG) model for quadruped walking. Demyelination is the degradation of the myelin layer covering the axons which can be caused by several neurodegenerative autoimmune diseases such as multiple sclerosis. We use this model - to our knowledge first of its kind - to investigate the locomotion deficits that appear following demyelination of axons in the spinal cord. Our model meets several physiological and behavioral results and predicts that whereas locomotion can still occur at high percentages of demyelination damage, the distribution and location of the lesion are the most critical factors for the locomotor performance.",

author = "Biljana Petreska and Yossi Yovel",

year = "2008",

doi = "10.1109/IJCNN.2008.4634153",

language = "אנגלית",

isbn = "9781424418213",

series = "Proceedings of the International Joint Conference on Neural Networks",

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booktitle = "2008 International Joint Conference on Neural Networks, IJCNN 2008",

note = "null ; Conference date: 01-06-2008 Through 08-06-2008",

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Petreska, B & Yovel, Y 2008, A neural model of demyelination of the mouse spinal cord. in 2008 International Joint Conference on Neural Networks, IJCNN 2008., 4634153, Proceedings of the International Joint Conference on Neural Networks, pp. 2538-2544, 2008 International Joint Conference on Neural Networks, IJCNN 2008, Hong Kong, China, 1/06/08. https://doi.org/10.1109/IJCNN.2008.4634153

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AB - This paper presents a neural network model of demyelination of the mouse motor pathways, coupled to a central pattern generation (CPG) model for quadruped walking. Demyelination is the degradation of the myelin layer covering the axons which can be caused by several neurodegenerative autoimmune diseases such as multiple sclerosis. We use this model - to our knowledge first of its kind - to investigate the locomotion deficits that appear following demyelination of axons in the spinal cord. Our model meets several physiological and behavioral results and predicts that whereas locomotion can still occur at high percentages of demyelination damage, the distribution and location of the lesion are the most critical factors for the locomotor performance.

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A neural model of demyelination of the mouse spinal cord

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