A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat

Cristobal Uauy; Assaf Distelfeld; Tzion Fahima; Ann Blechl; Jorge Dubcovsky

doi:10.1126/science.1133649

A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat

Cristobal Uauy, Assaf Distelfeld, Tzion Fahima, Ann Blechl, Jorge Dubcovsky^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.

Original language	English
Pages (from-to)	1298-1301
Number of pages	4
Journal	Science
Volume	314
Issue number	5803
DOIs	https://doi.org/10.1126/science.1133649
State	Published - 24 Nov 2006
Externally published	Yes

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10.1126/science.1133649

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abstract = "Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.",

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AU - Uauy, Cristobal

AU - Distelfeld, Assaf

AU - Fahima, Tzion

AU - Blechl, Ann

AU - Dubcovsky, Jorge

PY - 2006/11/24

Y1 - 2006/11/24

N2 - Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.

AB - Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.

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JO - Science

JF - Science

SN - 0036-8075

IS - 5803

ER -

A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat

Abstract

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