TY - JOUR
T1 - A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat
AU - Uauy, Cristobal
AU - Distelfeld, Assaf
AU - Fahima, Tzion
AU - Blechl, Ann
AU - Dubcovsky, Jorge
PY - 2006/11/24
Y1 - 2006/11/24
N2 - Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.
AB - Enhancing the nutritional value of food crops is a means of improving human nutrition and health. We report here the positional cloning of Gpc-B1, a wheat quantitative trait locus associated with increased grain protein, zinc, and iron content. The ancestral wild wheat allele encodes a NAC transcription factor (NAM-B1) that accelerates senescence and increases nutrient remobilization from leaves to developing grains, whereas modern wheat varieties carry a nonfunctional NAM-B1 allele. Reduction in RNA levels of the multiple NAM homologs by RNA interference delayed senescence by more than 3 weeks and reduced wheat grain protein, zinc, and iron content by more than 30%.
UR - http://www.scopus.com/inward/record.url?scp=33751567544&partnerID=8YFLogxK
U2 - 10.1126/science.1133649
DO - 10.1126/science.1133649
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AN - SCOPUS:33751567544
VL - 314
SP - 1298
EP - 1301
JO - Science
JF - Science
SN - 0036-8075
IS - 5803
ER -
