A multimodal nano agent for image-guided cancer surgery

Jinzi Zheng; Nidal Muhanna; Raquel De Souza; Hironobu Wada; Harley Chan; Margarete K. Akens; Takashi Anayama; Kazuhiro Yasufuku; Stefano Serra; Jonathan Irish; Christine Allen; David Jaffray

doi:10.1016/j.biomaterials.2015.07.010

A multimodal nano agent for image-guided cancer surgery

Jinzi Zheng^*, Nidal Muhanna, Raquel De Souza, Hironobu Wada, Harley Chan, Margarete K. Akens, Takashi Anayama, Kazuhiro Yasufuku, Stefano Serra, Jonathan Irish, Christine Allen, David Jaffray

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Intraoperative imaging technologies including computed tomography and fluorescence optical imaging are becoming routine tools in the cancer surgery operating room. They constitute an enabling platform for high performance surgical resections that assure local control while minimizing morbidity. New contrast agents that can increase the sensitivity and visualization power of existing intraoperative imaging techniques will further enhance their clinical benefit. We report here the development, detection and visualization of a dual-modality computed tomography and near-infrared fluorescence nano liposomal agent (CF800) in multiple preclinical animal models of cancer. We describe the successful application of this agent for combined preoperative computed tomography based three-dimensional surgical planning and intraoperative target mapping (>200 Hounsfield Units enhancement), as well as near-infrared fluorescence guided resection (>5-fold tumor-to-background ratio). These results strongly support the clinical advancement of this agent for image-guided surgery with potential to improve lesion localization, margin delineation and metastatic lymph node detection.

Original language	English
Pages (from-to)	160-168
Number of pages	9
Journal	Biomaterials
Volume	67
DOIs	https://doi.org/10.1016/j.biomaterials.2015.07.010
State	Published - 1 Oct 2015
Externally published	Yes

Keywords

Cancer
Computed tomography
Image-guided surgery
Liposomes
Multimodality imaging
Nearinfrared fluorescence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2015.07.010

Cite this

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title = "A multimodal nano agent for image-guided cancer surgery",

abstract = "Intraoperative imaging technologies including computed tomography and fluorescence optical imaging are becoming routine tools in the cancer surgery operating room. They constitute an enabling platform for high performance surgical resections that assure local control while minimizing morbidity. New contrast agents that can increase the sensitivity and visualization power of existing intraoperative imaging techniques will further enhance their clinical benefit. We report here the development, detection and visualization of a dual-modality computed tomography and near-infrared fluorescence nano liposomal agent (CF800) in multiple preclinical animal models of cancer. We describe the successful application of this agent for combined preoperative computed tomography based three-dimensional surgical planning and intraoperative target mapping (>200 Hounsfield Units enhancement), as well as near-infrared fluorescence guided resection (>5-fold tumor-to-background ratio). These results strongly support the clinical advancement of this agent for image-guided surgery with potential to improve lesion localization, margin delineation and metastatic lymph node detection.",

keywords = "Cancer, Computed tomography, Image-guided surgery, Liposomes, Multimodality imaging, Nearinfrared fluorescence",

author = "Jinzi Zheng and Nidal Muhanna and {De Souza}, Raquel and Hironobu Wada and Harley Chan and Akens, {Margarete K.} and Takashi Anayama and Kazuhiro Yasufuku and Stefano Serra and Jonathan Irish and Christine Allen and David Jaffray",

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year = "2015",

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doi = "10.1016/j.biomaterials.2015.07.010",

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AU - Zheng, Jinzi

AU - Muhanna, Nidal

AU - De Souza, Raquel

AU - Wada, Hironobu

AU - Chan, Harley

AU - Akens, Margarete K.

AU - Anayama, Takashi

AU - Yasufuku, Kazuhiro

AU - Serra, Stefano

AU - Irish, Jonathan

AU - Allen, Christine

AU - Jaffray, David

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Intraoperative imaging technologies including computed tomography and fluorescence optical imaging are becoming routine tools in the cancer surgery operating room. They constitute an enabling platform for high performance surgical resections that assure local control while minimizing morbidity. New contrast agents that can increase the sensitivity and visualization power of existing intraoperative imaging techniques will further enhance their clinical benefit. We report here the development, detection and visualization of a dual-modality computed tomography and near-infrared fluorescence nano liposomal agent (CF800) in multiple preclinical animal models of cancer. We describe the successful application of this agent for combined preoperative computed tomography based three-dimensional surgical planning and intraoperative target mapping (>200 Hounsfield Units enhancement), as well as near-infrared fluorescence guided resection (>5-fold tumor-to-background ratio). These results strongly support the clinical advancement of this agent for image-guided surgery with potential to improve lesion localization, margin delineation and metastatic lymph node detection.

AB - Intraoperative imaging technologies including computed tomography and fluorescence optical imaging are becoming routine tools in the cancer surgery operating room. They constitute an enabling platform for high performance surgical resections that assure local control while minimizing morbidity. New contrast agents that can increase the sensitivity and visualization power of existing intraoperative imaging techniques will further enhance their clinical benefit. We report here the development, detection and visualization of a dual-modality computed tomography and near-infrared fluorescence nano liposomal agent (CF800) in multiple preclinical animal models of cancer. We describe the successful application of this agent for combined preoperative computed tomography based three-dimensional surgical planning and intraoperative target mapping (>200 Hounsfield Units enhancement), as well as near-infrared fluorescence guided resection (>5-fold tumor-to-background ratio). These results strongly support the clinical advancement of this agent for image-guided surgery with potential to improve lesion localization, margin delineation and metastatic lymph node detection.

KW - Cancer

KW - Computed tomography

KW - Image-guided surgery

KW - Liposomes

KW - Multimodality imaging

KW - Nearinfrared fluorescence

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JO - Biomaterials

JF - Biomaterials

ER -

A multimodal nano agent for image-guided cancer surgery

Abstract

Keywords

UN SDGs

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