A medical nutriment has supportive value in the treatment of colorectal cancer

F. Jakab, Y. Shoenfeld*, Á Balogh, M. Nichelatti, A. Hoffmann, Zs Kahán, K. Lapis, Á Mayer, P. Sápy, F. Szentpétery, A. Telekes, L. Thurzó, A. Vágvölgyi, M. Hidvégi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

MSC (Avemar) is a medical nutriment of which preclinical and observational clinical studies suggested an antimetastatic activity with no toxicity. This open-label cohort trial has compared anticancer treatments plus MSC (9 g once daily) vs anticancer treatments alone in colorectal patients, enrolled from three oncosurgical centres; cohort allocation was on the basis of patients' choice. Sixty-six colorectal cancer patients received MSC supplement for more than 6 months and 104 patients served as controls (anticancer therapies alone): no statistical difference was noted in the time from diagnosis to the last visit between the two groups. End-point analysis revealed that progression-related events were significantly less frequent in the MSC group (new recurrences: 3.0 vs 17.3%, P < 0.01; new metastases: 7.6 vs 23.1%, P < 0.01; deaths: 12.1 vs 31.7%, P < 0.01 ). Survival analysis showed significant improvements in the MSC group regarding progression-free (P = 0.0184) and overall survivals (P = 0.0278) probabilities. Survival predictors in Cox's proportional hazards were UICC stage and MSC treatment. Continuous supplementation of anticancer therapies with MSC for more than 6 months is beneficial to patients with colorectal cancer in terms of overall and progression-free survival.

Original languageEnglish
Pages (from-to)465-469
Number of pages5
JournalBritish Journal of Cancer
Volume89
Issue number3
DOIs
StatePublished - 4 Aug 2003

Keywords

  • Cohort study
  • Colorectal cancer
  • Fermented wheat germ extract
  • Progression-free and overall survival

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