A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg; Aviya Dvir Ifrah; Tzipi Strauss; Michal J. Simchen; Raoul Orvieto; Nurit Rosenberg; Gili Kenet

doi:10.1002/pbc.26447

A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

Assaf Arie Barg^*, Aviya Dvir Ifrah, Tzipi Strauss, Michal J. Simchen, Raoul Orvieto, Nurit Rosenberg, Gili Kenet

^*Corresponding author for this work

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Abstract

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

Original language	English
Article number	e26447
Journal	Pediatric Blood and Cancer
Volume	64
Issue number	8
DOIs	https://doi.org/10.1002/pbc.26447
State	Published - Aug 2017

Keywords

HPA
Turner syndrome
neonatal thrombocytopenia
oocyte donor
surrogate pregnancy

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abstract = "The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.",

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AU - Orvieto, Raoul

AU - Rosenberg, Nurit

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A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

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