TY - JOUR
T1 - A longitudinal PRINTO study on growth and puberty in juvenile systemic lupus erythematosus
AU - Rygg, Marite
AU - Pistorio, Angela
AU - Ravelli, Angelo
AU - Maghnie, Mohamad
AU - Iorgi, Natascia Di
AU - Bader-Meunier, Brigitte
AU - Da Silva, Carlos
AU - Roldan-Molina, Rosa
AU - Barash, Judith
AU - Dracou, Cristina
AU - Laloum, Sylvie Gandon
AU - Jarosova, Katerina
AU - Deslandre, Chantal Job
AU - Koné-Paut, Isabelle
AU - Garofalo, Franco
AU - Press, Joseph
AU - Sengler, Claudia
AU - Tauber, Tsivia
AU - Martini, Alberto
AU - Ruperto, Nicolino
PY - 2012/4
Y1 - 2012/4
N2 - Objective: To obtain longitudinal data on growth/puberty in a large-scale, multi-national prospective cohort of juvenile systemic lupus erythematosus (SLE). Methods: Data from 331/557 (59.4%) patients ≤18 years old with juvenile SLE in active phase, with anthropometric data available at four follow-up visits, were studied. Results: There was a significant reduction in parent-adjusted height z score with time in females and males (p<0.0001), with a significant gender difference (p<0.0001) and with male height being most affected. Median body mass index z score peaked at 6 months and was still significantly above baseline after 26 months (p<0.01), with no gender difference. Standardised height reduction was inversely related to age at onset. Females with onset age <12 years had a median parent-adjusted height z score of -0.87 with no catch-up growth. At the end of the study, growth failure was seen in 14.7% of the females and 24.5% of the males. Height deflection (less than -0.25/year) was found in 20.7% of the females and 45.5% of the males. Delayed pubertal onset was seen in 15.3% and 24% of the females and males, respectively, and delayed/absent menarche was seen in 21.9%, while 36.1% of the females and 44% of the males had some degree of delayed pubertal development. Growth failure baseline determinants were previous growth failure (OR: 56.6), age at first visit ≤13.4 years (OR: 4.2) and cumulative steroid dose >426 mg/kg (OR: 3.6). Conclusions: The children at risk of having a negative effect on height and pubertal development are prepubertal and peripubertal children treated with >400 mg/kg cumulative dose of corticosteroids.
AB - Objective: To obtain longitudinal data on growth/puberty in a large-scale, multi-national prospective cohort of juvenile systemic lupus erythematosus (SLE). Methods: Data from 331/557 (59.4%) patients ≤18 years old with juvenile SLE in active phase, with anthropometric data available at four follow-up visits, were studied. Results: There was a significant reduction in parent-adjusted height z score with time in females and males (p<0.0001), with a significant gender difference (p<0.0001) and with male height being most affected. Median body mass index z score peaked at 6 months and was still significantly above baseline after 26 months (p<0.01), with no gender difference. Standardised height reduction was inversely related to age at onset. Females with onset age <12 years had a median parent-adjusted height z score of -0.87 with no catch-up growth. At the end of the study, growth failure was seen in 14.7% of the females and 24.5% of the males. Height deflection (less than -0.25/year) was found in 20.7% of the females and 45.5% of the males. Delayed pubertal onset was seen in 15.3% and 24% of the females and males, respectively, and delayed/absent menarche was seen in 21.9%, while 36.1% of the females and 44% of the males had some degree of delayed pubertal development. Growth failure baseline determinants were previous growth failure (OR: 56.6), age at first visit ≤13.4 years (OR: 4.2) and cumulative steroid dose >426 mg/kg (OR: 3.6). Conclusions: The children at risk of having a negative effect on height and pubertal development are prepubertal and peripubertal children treated with >400 mg/kg cumulative dose of corticosteroids.
UR - http://www.scopus.com/inward/record.url?scp=84857912567&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2011-200106
DO - 10.1136/annrheumdis-2011-200106
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C2 - 21998114
AN - SCOPUS:84857912567
SN - 0003-4967
VL - 71
SP - 511
EP - 517
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 4
ER -