A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

Malka Cohen-Armon

doi:10.3390/cells11091576

A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

Malka Cohen-Armon^*

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.

Original language	English
Article number	1576
Journal	Cells
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/cells11091576
State	Published - 1 May 2022

Keywords

DNA methylation
H1 polyADP-ribosylation
PARP1 activation
histone acetylation
immediate early gene expression
signal transduction pathways

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells11091576

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abstract = "This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.",

keywords = "DNA methylation, H1 polyADP-ribosylation, PARP1 activation, histone acetylation, immediate early gene expression, signal transduction pathways",

author = "Malka Cohen-Armon",

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AB - This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.

KW - DNA methylation

KW - H1 polyADP-ribosylation

KW - PARP1 activation

KW - histone acetylation

KW - immediate early gene expression

KW - signal transduction pathways

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A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

Abstract

Keywords

UN SDGs

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