A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

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Abstract

This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.

Original languageEnglish
Article number1576
JournalCells
Volume11
Issue number9
DOIs
StatePublished - 1 May 2022

Keywords

  • DNA methylation
  • H1 polyADP-ribosylation
  • histone acetylation
  • immediate early gene expression
  • PARP1 activation
  • signal transduction pathways

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