Abstract
This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.
Original language | English |
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Article number | 1576 |
Journal | Cells |
Volume | 11 |
Issue number | 9 |
DOIs | |
State | Published - 1 May 2022 |
Keywords
- DNA methylation
- H1 polyADP-ribosylation
- PARP1 activation
- histone acetylation
- immediate early gene expression
- signal transduction pathways