TY - JOUR
T1 - A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression
AU - Cohen-Armon, Malka
N1 - Publisher Copyright:
© 2022 by the author. Licensee MDPI, Basel, Switzerland.
PY - 2022/5/1
Y1 - 2022/5/1
N2 - This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.
AB - This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.
KW - DNA methylation
KW - H1 polyADP-ribosylation
KW - histone acetylation
KW - immediate early gene expression
KW - PARP1 activation
KW - signal transduction pathways
UR - http://www.scopus.com/inward/record.url?scp=85129586815&partnerID=8YFLogxK
U2 - 10.3390/cells11091576
DO - 10.3390/cells11091576
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 35563882
AN - SCOPUS:85129586815
VL - 11
JO - Cells
JF - Cells
SN - 2073-4409
IS - 9
M1 - 1576
ER -