A Locus for Complicated Hereditary Spastic Paraplegia Maps to Chromosome 1q24-q32

Sergiu C. Blumen, Simon Bevan, Saif Abu-Mouch, David Negus, Michael Kahana, Rifka Inzelberg, Aziz Mazarib, Ahmad Mahamid, Ralph L. Carasso, Hanoch Slor, David Withers, Puiu Nisipeanu, Ruth Navon, Evan Reid

Research output: Contribution to journalArticlepeer-review

Abstract

We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identified a new locus (SPG23) for this form of hereditary spastic paraplegia, in an approximately 25cM region of chromosome 1q24-q32, with a peak logarithm of odds score of 3.05.

Original languageEnglish
Pages (from-to)796-803
Number of pages8
JournalAnnals of Neurology
Volume54
Issue number6
DOIs
StatePublished - Dec 2003

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