A Locus for Complicated Hereditary Spastic Paraplegia Maps to Chromosome 1q24-q32

Sergiu C. Blumen; Simon Bevan; Saif Abu-Mouch; David Negus; Michael Kahana; Rifka Inzelberg; Aziz Mazarib; Ahmad Mahamid; Ralph L. Carasso; Hanoch Slor; David Withers; Puiu Nisipeanu; Ruth Navon; Evan Reid

doi:10.1002/ana.10768

A Locus for Complicated Hereditary Spastic Paraplegia Maps to Chromosome 1q24-q32

Sergiu C. Blumen, Simon Bevan, Saif Abu-Mouch, David Negus, Michael Kahana, Rifka Inzelberg, Aziz Mazarib, Ahmad Mahamid, Ralph L. Carasso, Hanoch Slor, David Withers, Puiu Nisipeanu, Ruth Navon, Evan Reid^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identified a new locus (SPG23) for this form of hereditary spastic paraplegia, in an approximately 25cM region of chromosome 1q24-q32, with a peak logarithm of odds score of 3.05.

Original language	English
Pages (from-to)	796-803
Number of pages	8
Journal	Annals of Neurology
Volume	54
Issue number	6
DOIs	https://doi.org/10.1002/ana.10768
State	Published - Dec 2003

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10.1002/ana.10768

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title = "A Locus for Complicated Hereditary Spastic Paraplegia Maps to Chromosome 1q24-q32",

abstract = "We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identified a new locus (SPG23) for this form of hereditary spastic paraplegia, in an approximately 25cM region of chromosome 1q24-q32, with a peak logarithm of odds score of 3.05.",

author = "Blumen, {Sergiu C.} and Simon Bevan and Saif Abu-Mouch and David Negus and Michael Kahana and Rifka Inzelberg and Aziz Mazarib and Ahmad Mahamid and Carasso, {Ralph L.} and Hanoch Slor and David Withers and Puiu Nisipeanu and Ruth Navon and Evan Reid",

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AU - Blumen, Sergiu C.

AU - Bevan, Simon

AU - Abu-Mouch, Saif

AU - Negus, David

AU - Kahana, Michael

AU - Inzelberg, Rifka

AU - Mazarib, Aziz

AU - Mahamid, Ahmad

AU - Carasso, Ralph L.

AU - Slor, Hanoch

AU - Withers, David

AU - Nisipeanu, Puiu

AU - Navon, Ruth

AU - Reid, Evan

PY - 2003/12

Y1 - 2003/12

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AB - We updated the clinical features of a consanguineous Arab Israeli family, in which four of seven children were affected by spastic paraplegia complicated by skin pigmentary abnormalities. A genomewide linkage screen performed for the family identified a new locus (SPG23) for this form of hereditary spastic paraplegia, in an approximately 25cM region of chromosome 1q24-q32, with a peak logarithm of odds score of 3.05.

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JO - Annals of Neurology

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IS - 6

ER -

A Locus for Complicated Hereditary Spastic Paraplegia Maps to Chromosome 1q24-q32

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