A Linear-Time Algorithm for the Copy Number Transformation Problem

Problems of genome rearrangement are central in both evolution and cancer. Most evolutionary scenarios have been studied under the assumption that the genome contains a single copy of each gene. In contrast, tumor genomes undergo deletions and duplications, and thus, the number of copies of genes varies. The number of copies of each segment along a chromosome is called its copy number profile (CNP). Understanding CNP changes can assist in predicting disease progression and treatment. To date, questions related to distances between CNPs gained little scientific attention. Here we focus on the following fundamental problem, introduced by Schwarz et al.: given two CNPs, u and v, compute the minimum number of operations transforming u into v, where the edit operations are segmental deletions and amplifications. We establish the computational complexity of this problem, showing that it is solvable in linear time and constant space.