A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli

Ilana Kolodkin-Gal, Ronen Hazan, Ariel Gaathon, Shmuel Carmeli, Hanna Engelberg-Kulka

Research output: Contribution to journalArticlepeer-review

Abstract

mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.

Original languageEnglish
Pages (from-to)652-655
Number of pages4
JournalScience
Volume318
Issue number5850
DOIs
StatePublished - 26 Oct 2007

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