A hypodiploid clone and its duplicate in acute lymphoblastic leukemia

F. Shabtai, U. H. Lewinski, L. Har-Zahav, U. Gafter, I. Halbrecht, M. Djaldetti

Research output: Contribution to journalArticlepeer-review


Examination of the bone marrow of a 63-year-old man who had acute lymphoblastic leukemia revealed a population of cells with 32 chromosomes and another population with 64 chromosomes, the karyotypic exact duplicate of the first clone. The karyotypic evolution was studied and the findings compared with those described in two similar cases previously reported. It is postulated that severe hypodiploidy is associated with reduced capability of cellular survival, promoting a strong tendency for duplication.

Original languageEnglish
Pages (from-to)1018-1024
Number of pages7
JournalAmerican Journal of Clinical Pathology
Issue number6
StatePublished - 1979


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