A hypodiploid clone and its duplicate in acute lymphoblastic leukemia

F. Shabtai; U. H. Lewinski; L. Har-Zahav; U. Gafter; I. Halbrecht; M. Djaldetti

doi:10.1093/ajcp/72.6.1018

A hypodiploid clone and its duplicate in acute lymphoblastic leukemia

F. Shabtai, U. H. Lewinski, L. Har-Zahav, U. Gafter, I. Halbrecht, M. Djaldetti

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Abstract

Examination of the bone marrow of a 63-year-old man who had acute lymphoblastic leukemia revealed a population of cells with 32 chromosomes and another population with 64 chromosomes, the karyotypic exact duplicate of the first clone. The karyotypic evolution was studied and the findings compared with those described in two similar cases previously reported. It is postulated that severe hypodiploidy is associated with reduced capability of cellular survival, promoting a strong tendency for duplication.

Original language	English
Pages (from-to)	1018-1024
Number of pages	7
Journal	American Journal of Clinical Pathology
Volume	72
Issue number	6
DOIs	https://doi.org/10.1093/ajcp/72.6.1018
State	Published - 1979

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AU - Halbrecht, I.

AU - Djaldetti, M.

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A hypodiploid clone and its duplicate in acute lymphoblastic leukemia

Abstract

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