A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23

Kinneret Savitsky, Yael Ziv, Anat Bar-Shira, Shlomit Gilad, Danilo A. Tagle, Sara Smith, Tamar Uziel, Sharon Sfez, Joseph Nahmias, Adam Sartiel, Roger L. Eddy, Thomas B. Shows, Francis S. Collins, Yosef Shiloh, Galit Rotman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23. The predicted amino acid sequence shows very high similarity to a subgroup of DEAD-box RNA helicases involved in ribosome biogenesis. This novel gene encodes a 3.2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalGenomics
Volume33
Issue number2
DOIs
StatePublished - 15 Apr 1996

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