@article{30c6802fe3ad4c4e9fa47770702c4caa,
title = "A highly conserved A-to-I RNA editing event within the glutamate-gated chloride channel GluClα is necessary for olfactory-based behaviors in Drosophila",
abstract = "A-to-I RNA editing is a cellular mechanism that generates transcriptomic and proteomic diversity, which is essential for neuronal and immune functions. It involves the conversion of specific adenosines in RNA molecules to inosines, which are recognized as guanosines by cellular machinery. Despite the vast number of editing sites observed across the animal kingdom, pinpointing critical sites and understanding their in vivo functions remains challenging. Here, we study the function of an evolutionary conserved editing site in Drosophila, located in glutamate-gated chloride channel (GluClα). Our findings reveal that flies lacking editing at this site exhibit reduced olfactory responses to odors and impaired pheromone-dependent social interactions. Moreover, we demonstrate that editing of this site is crucial for the proper processing of olfactory information in projection neurons. Our results highlight the value of using evolutionary conservation as a criterion for identifying editing events with potential functional significance and paves the way for elucidating the intricate link between RNA modification, neuronal physiology, and behavior.",
author = "Hila Zak and Eyal Rozenfeld and Mali Levi and Patricia Deng and David Gorelick and Hadar Pozeilov and Shai Israel and Yoav Paas and \{Billy Li\}, Jin and Moshe Parnas and Galit Shohat-Ophir",
note = "Publisher Copyright: Copyright {\textcopyright} 2024 The Authors, some rights reserved.",
year = "2024",
month = sep,
day = "6",
doi = "10.1126/sciadv.adi9101",
language = "אנגלית",
volume = "10",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "36",
}