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A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

  • Or David Shahar
  • , Alkmini Kalousi
  • , Lital Eini
  • , Benoit Fisher
  • , Amelie Weiss
  • , Jonatan Darr
  • , Olga Mazina
  • , Shay Bramson
  • , Martin Kupiec
  • , Amir Eden
  • , Eran Meshorer
  • , Alexander V. Mazin
  • , Laurent Brino
  • , Michal Goldberg*
  • , Evi Soutoglou
    • *Corresponding author for this work
  • Hebrew University of Jerusalem
  • Institut de Génétique et de Biologie Moléculaire et Cellulaire
  • Drexel University
  • Tel Aviv University

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

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Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science

Chemistry