@article{ed7dfc35b4814036a3375c315d149173,
title = "A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite",
abstract = "Previous investigations showed that a high molecular mass, non-dialyzable material (NDM) from cranberries inhibits the adhesion of a number of bacterial species and prevents the co-aggregation of many oral bacterial pairs. In the present study we determined the effect of mouthwash supplemented with NDM on oral hygiene. Following 6 weeks of daily usage of cranberry-containing mouthwash by an experimental group (n=29), we found that salivary mutans streptococci count as well as the total bacterial count were reduced significantly (ANOVA, P<0.01) compared with those of the control (n=30) using placebo mouthwash. No change in the plaque and gingival indices was observed. In vitro, the cranberry constituent inhibited the adhesion of Streptococcus sobrinus to saliva-coated hydroxyapatite. The data suggest that the ability to reduce mutans streptococci counts in vivo is due to the anti-adhesion activity of the cranberry constituent.",
keywords = "Anti-adhesion, Antibacterial, Cranberry, Hydroxyapatite, Mouthwash, Mutans streptococcus, Saliva",
author = "Weiss, {Ervin I.} and Avital Kozlovsky and Doron Steinberg and Ron Lev-Dor and Greenstein, {Ronit Bar Ness} and Mark Feldman and Nathan Sharon and Itzhak Ofek",
note = "Funding Information: This study was performed in part at the R. Goldstein Research Center, Faculty of Dentistry, Hebrew University-Hadassah, and at the Alpha Omega Research Laboratories, School of Dental Medicine, Tel Aviv University. The work was supported in part by a grant from Ocean Spray, Inc.",
year = "2004",
month = mar,
day = "12",
doi = "10.1016/S0378-1097(04)00035-7",
language = "אנגלית",
volume = "232",
pages = "89--92",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Oxford University Press",
number = "1",
}