A high molecular mass constituent of cranberry juice inhibits Helicobacter pylori adhesion to human gastric mucus

Ora Burger, Itzhak Ofek, Mina Tabak, Ervin I. Weiss, Nathan Sharon, Ishak Neeman

Research output: Contribution to journalArticlepeer-review

Abstract

Because previous studies have shown that a high molecular mass constituent of cranberry juice inhibited adhesion of Escherichia coli to epithelial cells and coaggregation of oral bacteria, we have examined its effect on the adhesion of Helicobacter pylori to immobilized human mucus and to erythrocytes. We employed three strains of H. pylori all of which bound to the mucus and agglutinated human erythrocytes via a sialic acid-specific adhesin. The results showed that a high molecular mass constituent derived from cranberry juice inhibits the sialic acid-specific adhesion of H. pylori to human gastric mucus and to human erythrocytes. (C) 2000 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume29
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Adhesion
  • Cranberry
  • Helicobacter pylori
  • Mucus

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