A global view of the selection forces in the evolution of yeast Cis-regulation

Amos Tanay*, Irit Gat-Viks, Ron Shamir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The interaction between transcription factors and their DNA binding sites is key to understanding gene regulation. By performing a genome-wide study of the evolutionary dynamics in yeast promoters, we provide a first global view of the network of selection forces in the evolution of transcription factor binding sites. This analysis gives rise to new models for binding site activity, identifies families of related binding sites, and characterizes the functional similarities among them. We discovered rich and highly optimized selective pressures operating inside and around these families. In several cases, this organization reveals that a single transcription factor has multiple functional modes. We demonstrate how such functional heterogeneity is related to the binding site's affinity and how it is exploited in transcription programs.

Original languageEnglish
Pages (from-to)829-834
Number of pages6
JournalGenome Research
Issue number5
StatePublished - May 2004


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