TY - JOUR
T1 - A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
AU - COVID Human Genetic Effort
AU - Andreakos, Evangelos
AU - Abel, Laurent
AU - Vinh, Donald C.
AU - Kaja, Elżbieta
AU - Drolet, Beth A.
AU - Zhang, Qian
AU - O’Farrelly, Cliona
AU - Novelli, Giuseppe
AU - Rodríguez-Gallego, Carlos
AU - Haerynck, Filomeen
AU - Prando, Carolina
AU - Pujol, Aurora
AU - Bastard, Paul
AU - Biggs, Catherine M.
AU - Bigio, Benedetta
AU - Boisson, Bertrand
AU - Bolze, Alexandre
AU - Bondarenko, Anastasiia
AU - Brodin, Petter
AU - Chakravorty, Samya
AU - Christodoulou, John
AU - Cobat, Aurelié
AU - Condino-Neto, Antonio
AU - Constantinescu, Stefan N.
AU - Feldman, Hagit Baris
AU - Fellay, Jacques
AU - Flores, Carlos
AU - Halwani, Rabih
AU - Jouanguy, Emmanuelle
AU - Lau, Yu Lung
AU - Meyts, Isabelle
AU - Mogensen, Trine H.
AU - Okada, Satoshi
AU - Okamoto, Keisuke
AU - Ozcelik, Tayfun
AU - Pan-Hammarström, Qiang
AU - Diego, Rebeca Pérez de
AU - Planas, Anna M.
AU - Puel, Anne
AU - Quintana-Murci, Lluis
AU - Renia, Laurent
AU - Resnick, Igor
AU - Sediva, Anna
AU - Shcherbina, Anna
AU - Slaby, Ondrej
AU - Tancevski, Ivan
AU - Turvey, Stuart E.
AU - Uddin, K. M.Furkan
AU - van de Beek, Diederik
AU - Zatz, Mayana
N1 - Publisher Copyright:
© 2021, Springer Nature America, Inc.
PY - 2022/2
Y1 - 2022/2
N2 - SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
AB - SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
UR - http://www.scopus.com/inward/record.url?scp=85117437869&partnerID=8YFLogxK
U2 - 10.1038/s41590-021-01030-z
DO - 10.1038/s41590-021-01030-z
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C2 - 34667308
AN - SCOPUS:85117437869
SN - 1529-2908
VL - 23
SP - 159
EP - 164
JO - Nature Immunology
JF - Nature Immunology
IS - 2
ER -
