A glitch in the matrix: organ-specific matrisomes in metastatic niches

Sarah K. Deasy, Neta Erez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-supportive organ niche. Recent work investigating ECM changes that facilitate metastasis has revealed ways in which different metastatic organ niches are similar as well as the distinct characteristics that make them unique. In this review, we present recent findings regarding how ECM modifications support metastasis in four frequent metastatic sites: the lung, liver, bone, and brain. We discuss ways in which these modifications are shared between metastatic organs as well as features specific to each location. We also discuss areas of technical innovation that could be advantageous to future research and areas of inquiry that merit further investigation.

Original languageEnglish
Pages (from-to)110-123
Number of pages14
JournalTrends in Cell Biology
Issue number2
StatePublished - Feb 2022


  • extracellular matrix
  • fibrosis
  • matrisome
  • metastasis
  • microenvironment
  • premetastatic niche


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