@article{bda928ce672e4eb6befae9e3cf9e5253,
title = "A formal MIM specification and tools for the common exchange of MIM diagrams: An XML-Based format, an API, and a validation method",
abstract = "Background: The Molecular Interaction Map (MIM) notation offers a standard set of symbols and rules on their usage for the depiction of cellular signaling network diagrams. Such diagrams are essential for disseminating biological information in a concise manner. A lack of software tools for the notation restricts wider usage of the notation. Development of software is facilitated by a more detailed specification regarding software requirements than has previously existed for the MIM notation.Results: A formal implementation of the MIM notation was developed based on a core set of previously defined glyphs. This implementation provides a detailed specification of the properties of the elements of the MIM notation. Building upon this specification, a machine-readable format is provided as a standardized mechanism for the storage and exchange of MIM diagrams. This new format is accompanied by a Java-based application programming interface to help software developers to integrate MIM support into software projects. A validation mechanism is also provided to determine whether MIM datasets are in accordance with syntax rules provided by the new specification.Conclusions: The work presented here provides key foundational components to promote software development for the MIM notation. These components will speed up the development of interoperable tools supporting the MIM notation and will aid in the translation of data stored in MIM diagrams to other standardized formats. Several projects utilizing this implementation of the notation are outlined herein. The MIM specification is available as an additional file to this publication. Source code, libraries, documentation, and examples are available at http://discover.nci.nih.gov/mim.",
author = "Augustin Luna and Karac, {Evrim I.} and Margot Sunshine and Lucas Chang and Ruth Nussinov and Aladjem, {Mirit I.} and Kohn, {Kurt W.}",
note = "Funding Information: We would like to acknowledge discussions with Can Ozturan, Mine Edes, and Turkan Haliloglu. Also, discussions with members of the SBGN and BioPAX communities were useful to the success of this project, especially Emek Demir, Nicolas Le Nov{\`e}re, and Hiroaki Kitano. Discussions with Martijn van Iersel were useful in understanding the GPML format. This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, as well as with Federal funds from the National Cancer Institute, National Institutes of Health, under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.",
year = "2011",
month = may,
day = "17",
doi = "10.1186/1471-2105-12-167",
language = "אנגלית",
volume = "12",
journal = "BMC Bioinformatics",
issn = "1471-2105",
publisher = "BioMed Central Ltd.",
}