TY - JOUR
T1 - A fatal effect of hornet venom on rat-brain cortical neurons
AU - Cohen-Armon, Malka
AU - Visochek, Leonid
AU - Priel, Esther
AU - Ishay, Jacob S.
PY - 2006
Y1 - 2006
N2 - In a previous study, it was shown that the hornet venom or, more specifically, its venom sac extract (VSE) possesses deoxyribonuclease activity that exerts an effect both on insects as well as on mammals. We have now examined the effect of hornet VSE on primary culture of rat cortical neurons. Judging on the basis of our results, VSE induces a rapid cell death by a) permeabilizing the cell membrane, b) inducing DNA breaks, and c) cleaving the nuclear protein poly-ADP-ribose polymerase (PARP-1), thereby preventing DNA repair.
AB - In a previous study, it was shown that the hornet venom or, more specifically, its venom sac extract (VSE) possesses deoxyribonuclease activity that exerts an effect both on insects as well as on mammals. We have now examined the effect of hornet VSE on primary culture of rat cortical neurons. Judging on the basis of our results, VSE induces a rapid cell death by a) permeabilizing the cell membrane, b) inducing DNA breaks, and c) cleaving the nuclear protein poly-ADP-ribose polymerase (PARP-1), thereby preventing DNA repair.
UR - https://www.scopus.com/pages/publications/33745053644
U2 - 10.1002/cbdv.200690057
DO - 10.1002/cbdv.200690057
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AN - SCOPUS:33745053644
SN - 1612-1872
VL - 3
SP - 535
EP - 543
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 5
ER -