A fatal effect of hornet venom on rat-brain cortical neurons

Malka Cohen-Armon, Leonid Visochek, Esther Priel, Jacob S. Ishay

Research output: Contribution to journalArticlepeer-review

Abstract

In a previous study, it was shown that the hornet venom or, more specifically, its venom sac extract (VSE) possesses deoxyribonuclease activity that exerts an effect both on insects as well as on mammals. We have now examined the effect of hornet VSE on primary culture of rat cortical neurons. Judging on the basis of our results, VSE induces a rapid cell death by a) permeabilizing the cell membrane, b) inducing DNA breaks, and c) cleaving the nuclear protein poly-ADP-ribose polymerase (PARP-1), thereby preventing DNA repair.

Original languageEnglish
Pages (from-to)535-543
Number of pages9
JournalChemistry and Biodiversity
Volume3
Issue number5
DOIs
StatePublished - 2006

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