@article{9d5406b36def4917814a101b5520a928,
title = "A dual-function phage regulator controls the response of cohabiting phage elements via regulation of the bacterial SOS response",
abstract = "Listeria monocytogenes strain 10403S harbors two phage elements in its chromosome; one produces infective virions and the other tailocins. It was previously demonstrated that induction of the two elements is coordinated, as they are regulated by the same anti-repressor. In this study, we identified AriS as another phage regulator that controls the two elements, bearing the capacity to inhibit their lytic induction under SOS conditions. AriS is a two-domain protein that possesses two distinct activities, one regulating the genes of its encoding phage and the other downregulating the bacterial SOS response. While the first activity associates with the AriS N-terminal AntA/AntB domain, the second associates with its C-terminal ANT/KilAC domain. The ANT/KilAC domain is conserved in many AriS-like proteins of listerial and non-listerial prophages, suggesting that temperate phages acquired such dual-function regulators to align their response with the other phage elements that cohabit the genome.",
keywords = "CP: Microbiology, KilAC, Listeria monocytogenes, SOS response, ant, bacteriophage, lysogeny, pathogen, phage",
author = "Gil Azulay and Anna Pasechnek and Olga Stadnyuk and Shai Ran-Sapir and Fleisacher, {Ana Mejia} and Ilya Borovok and Nadejda Sigal and Herskovits, {Anat A.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = apr,
day = "19",
doi = "10.1016/j.celrep.2022.110723",
language = "אנגלית",
volume = "39",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}