A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Elad Lax; Gal Warhaftig; David Ohana; Rachel Maayan; Yael Delayahu; Paola Roska; Alexander M. Ponizovsky; Avraham Weizman; Gal Yadid; Moshe Szyf

doi:10.3389/fnmol.2018.00322

A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Elad Lax
, Gal Warhaftig
, David Ohana
, Rachel Maayan
, Yael Delayahu
, Paola Roska
, Alexander M. Ponizovsky
, Avraham Weizman
, Gal Yadid^*
, Moshe Szyf

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.

Original language	English
Article number	322
Journal	Frontiers in Molecular Neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fnmol.2018.00322
State	Published - 10 Sep 2018

Funding

Funders	Funder number
Canadian Institute for Health Research
Government of Quebec	238658 MESRST PSR-SIIRI-854
Israel Anti-Drug Authority
McGill University
Canadian Institutes of Health Research	MOP-42411

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DNA methylation
Dehydroepiandrosterone (DHEA)
Drug abuse
Drug-addiction
Genome-wide analysis

Access to Document

10.3389/fnmol.2018.00322

Cite this

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title = "A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention",

abstract = "Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.",

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AU - Lax, Elad

AU - Warhaftig, Gal

AU - Ohana, David

AU - Maayan, Rachel

AU - Delayahu, Yael

AU - Roska, Paola

AU - Ponizovsky, Alexander M.

AU - Weizman, Avraham

AU - Yadid, Gal

AU - Szyf, Moshe

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KW - Dehydroepiandrosterone (DHEA)

KW - Drug abuse

KW - Drug-addiction

KW - Genome-wide analysis

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A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention

Abstract

Funding

UN SDGs

Keywords

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