@article{04e5713e245c4bcebb68c3e5f7adfeef,
title = "A DNA Methylation Signature of Addiction in T Cells and Its Reversal With DHEA Intervention",
abstract = "Previous studies in animal models of cocaine craving have delineated broad changes in DNA methylation profiles in the nucleus accumbens. A crucial factor for progress in behavioral and mental health epigenetics is the discovery of epigenetic markers in peripheral tissues. Several studies in primates and humans have associated differences in behavioral phenotypes with changes in DNA methylation in T cells and brain. Herein, we present a pilot study (n = 27) showing that the T cell DNA methylation profile differentiates persons with a substance use disorder from controls. Intervention with dehydroepiandrosterone (DHEA), previously shown to have a long-term therapeutic effect on human addicts herein resulted in reversal of DNA methylation changes in genes related to pathways associated with the addictive state.",
keywords = "DNA methylation, Dehydroepiandrosterone (DHEA), Drug abuse, Drug-addiction, Genome-wide analysis",
author = "Elad Lax and Gal Warhaftig and David Ohana and Rachel Maayan and Yael Delayahu and Paola Roska and Ponizovsky, {Alexander M.} and Avraham Weizman and Gal Yadid and Moshe Szyf",
note = "Publisher Copyright: {\textcopyright} 2018 Lax, Warhaftig, Ohana, Maayan, Delayahu, Roska, Ponizovsky, Weizman, Yadid and Szyf. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
month = sep,
day = "10",
doi = "10.3389/fnmol.2018.00322",
language = "אנגלית",
volume = "11",
journal = "Frontiers in Molecular Neuroscience",
issn = "1662-5099",
publisher = "Frontiers Media S.A.",
}