A direct effect of α-chlorohydrin on motility and metabolism of ejaculated human spermatozoa

Zvi T. Homonnai*, Gedalia Paz, Adin Sofer, Gideon A. Yedwab, Perez F. Kraicer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Human spermatozoa were incubated in vitro in the presence of α-chlorohydrin at concentrations which inhibited motility, but which were not spermicidal. The inhibition of motility was not reversed by washing or by addition of α-glycerophosphate. Metabolic activity of the spermatozoa was reduced, as measured by glucose, oxygen uptake and lactate production. Endogenous respiration was not affected. Cyclic AMP levels were reduced. Thus, at least part of the adversed effects of α-chlorohydrin on male fertility may be due to direct inhibitory action on the spermatozoa.

Original languageEnglish
Pages (from-to)579-588
Number of pages10
JournalContraception
Volume12
Issue number5
DOIs
StatePublished - Nov 1975
Externally publishedYes

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