A differential scanning calorimetry study of the interaction of gangliosides with peanut lectin, serotonin and daunomycin

Diana Bach*, Ben Ami Sela

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Thermotropic behaviour of human Tay-Sachs ganglioside and of mixed bovine brain gangliosides, before and after interaction with peanut lectin, serotonin and daunomycin, was investigated. Interaction of mixed brain gangliosides with peanut lectin or serotonin causes a decrease in the enthalpy of melting, whereas interaction of this lectin with Tay-Sachs ganglioside does not influence the enthalpy of melting. Serotonin causes a small increase in the enthalpy of melting of the Tay-Sachs ganglioside.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalBBA - Biomembranes
Volume596
Issue number2
DOIs
StatePublished - 28 Feb 1980
Externally publishedYes

Funding

FundersFunder number
Israel Cancer Research Fund
Volkswagen Foundation11-2711

    Keywords

    • (Peanut)
    • Daunomycin
    • Lectin
    • Serotonin
    • Tay-Sachs ganglioside
    • Thermotropic behavior

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